Using indicators to further implementation of Responsible Research and Innovation is a cornerstone in EC policymaking and generally seen as a good practice. The RRI-Practice project provides evidence that using indicators is far from unproblematic. Where indicators may have advantages, we provide evidence that indicators may cause outright resistance to RRI and may be seen as curbing learning. Indicator use vary considerably along national norms, and organizational cultures. It is important to use indicators that facilitate learning processes, use measurements that further, rather than curb, RRI, and take up as few resources as possible with respect to reporting. We further show that evaluations, which include users, are a viable alternative to indicators with respect to implementation of responsible research and innovation. Additionally, if national funding providers are to employ indicators, indicators need to be sanctioned by higher level governance actors. We finish with practical advice on working with indicators.