The LDL receptor family is known to bind and internalize apoE-rich lipoproteins, and thought to play a role in lipoprotein metabolism. The recently identified new members showed the structural heterogeneity in the family, and molecular biological approach using animal models revealed the essential biological function in neural development. These increasing novel findings suggest that the LDL receptor family is a cluster of multifunctional receptors for intracellular signal transduction, neuron migration and vascular smooth muscle cell proliferation, as well as lipoprotein incorporation.