[Antibodies against nerve tissue proteins S100, GFAP, and MP65 and pregnant women with early toxemia].

descriptionPublicationkeyboard_double_arrow_right Article 13 Mar 2000 Russian Journal:Voprosy meditsinskoi khimii, volume 44 (issn: 0042-8809,

Authors: S G, Morozov; A B, Poletaev; L E, Murashko; E P, D'iakova; I V, Ponomareva; B B, Gnedenko; G T, Sukhikh;

pmid: 10599145

[Antibodies against nerve tissue proteins S100, GFAP, and MP65 and pregnant women with early toxemia].

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Abstract

Serum levels/affinities of natural autoantibodies to proteins S100, GFAP and MP65 in patients with physiological pregnancy are usually constant and may vary among individuals within relatively narrow range. In patients with early toxicosis in pregnancy dispersion of serum autoantibodies levels were often found beyond the normal range. This group includes cases with significantly elevated as well as abnormally decreased immunoreactivity parameters. Percent of newborns with different deviations from women with abnormal serum levels/affinities of autoantibodies to proteins S100, GFAP and MP65 was higher 1,5-2 fold compared with population.

Related Organizations

Department of Medical Sciences
Russian Federation
Institute of Biomedical Chemistry
Russian Federation

Keywords

Adult, Integrins, Membrane Glycoproteins, Adolescent, S100 Proteins, Enzyme-Linked Immunosorbent Assay, Pre-Eclampsia, Pregnancy, Glial Fibrillary Acidic Protein, Humans, Female, Autoantibodies

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