Enteroviruses are the causative agents of multiple diseases in humans and animals, affecting nearly one billion people annually worldwide. Disease manifestations includes meningitis poliomyelitis, respiratory infection, undifferentiated febrile illness, acute gastroenteritis, Bornholm disease as well as foot hand and mouth disease. Enteroviruses, along with rhinovirus and poliovirus belong to the Picornaviridae family. Although the virology lab of Hamad Medical Corporation (HMC) screen for enteroviruses for multiple diseases, there is limited data about molecular epidemiology and clinical manifestation about these infections in Qatar. Qatar is a multi-national country, The expats arrive from many countries around the globe, mainly from South East Asia and MENA region. This increases the risk for introduction of various communicable diseases, including various enteroviruses, to the country