
handle: 10553/74052 , 10550/66109
Se realiza un estudio histoquímico, con la técnica del azul alcián, en la fisis tibial de ratas machos de un mes diabetizadas mediante inyección de streptozotocin. Se comparan los resultados con un grupo control comprobándose que tras la primera semana, aunque las fisis diabéticas son más estrechas, no existen diferencias en la captación del colorante; a partir de la segunda semana éstas muestran progresivamente menor avidez por el azul alcián que los controles, indicando una menor producción de proteoglicanos, especialmente a nivel germinal y proliferativo. La precocidad en la aparición de alteraciones sugiere el observar más concienzudamente la posibilidad de problemas ortopédicos en el crecimiento de niños diabéticos, especialmente aquellos diagnosticados con retraso.
A histochemical study, Alcian Blue technique, was made on the growth plate of the tibia in streptozotocin induced diabetic male rats. Results were compared with a control group. After the first week, although diabetic growth plates were thinner than controls, no differences in staining were found; from the second week diabetic epiphyseal plates progressively showed less avidity for Alcian Blue than control plates, mainly at the resting and proliferative zones. Because of the early changes in the growth plates of the rats, doser observation of diabetic children, specially those diagnosed with delay, is advised.
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Cartílago de crecimiento, Histoquímica, 310910 Cirugía, UNESCO::CIENCIAS MÉDICAS, Diabetes, Growth Plate, Histochemical
Cartílago de crecimiento, Histoquímica, 310910 Cirugía, UNESCO::CIENCIAS MÉDICAS, Diabetes, Growth Plate, Histochemical
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