
handle: 10553/48891
Evaluamos la influencia de los niveles de Iípidos plasmáticos aportados en la nutrición parenteral sobre la unión bilirrubina-albúmina de 12 recién nacidos a término portadores de patologías severas. Como controles se seleccionaron 2 grupos de igual número de neonatos, pero que estaban alimentados con lactancia materna o artificial. La capacidad de reserva de unión de la albúmina descendió en los recién nacidos sometidos a nutrición parenteral (52,3 frente a 72,9/73,5). Esta disminución se correlacionó con mayores concentraciones de ácidos grasos libres (r = 0,9234, p < 0, 001 ), colesterol (r =0,9049, p < 0,001) y triglicéridos (r = 0,8802, p < 0,001). La clara influencia de los parámetros lipídicos estudiados sobre la unión bilirrubina-albúmina nos invita apensar en el uso sistemático de heparina para movilizar la lipoproteín-lipasa del endotelio vascular y promover un mejor manejo de los lípidos en los neonatos a término, sobre todo si existe hiperbilirrubinemia importante.
We evaluate the influence of plasma lipid levels supplied in parenteral nutrition, on the bilirubin-albumin binding of 12 term newborns with severe pathologies. As controls we selected 2 groups of an equal number o newborns who were receiving maternal or artificial lactation. The reserved albumin binding capacity decreased in newborns subjected to parenteral nutrition (52.3 versus 72.9/73.5). This decrease correlated positively with greater concentrations of free fatty acids (r = 0.9234, p < 0.001), cholesterol (r = 0.9049, p < 0.001), and triglycerides (r = 0.8802, p < 0.001). The clear influence of the studied lipid parameters on the bilirubin albumin binding, invites us to consider the systematic use of heparin for the mobilization of lipoprotein-lipase from the vascular endothelium and to promote a better management of lipids in term newborns, especially if there is an important hyperbilirubinemia.
SCIE
205
201
5
Bilirrubina, Recién nacido, Lípidos, Bilirubin, Nutrición parenteral, 320110 Pediatría, Newborn, Parenteral nutrition, 32 Ciencias médicas, Lipids
Bilirrubina, Recién nacido, Lípidos, Bilirubin, Nutrición parenteral, 320110 Pediatría, Newborn, Parenteral nutrition, 32 Ciencias médicas, Lipids
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