The Canary Current Large Marine Ecosystem (CCLME) ranks third in the world in terms of primary productivity and has one of the highest fisheries production of any African large marine ecosystem with an annual production ranging from 2 to 3 million tons. The CCLME waters exhibit high abundance and biomass and a rich cephalopod fauna in comparison with other areas of the world’s oceans. These waters are a transitional zone between different Atlantic zoogeographic provinces where tropical, temperate and cold water cephalopod species mix. Several assemblages can be identified in the coastal, shelf, slope and deep waters. Coastal assemblages are dominated by sepiids, loliginids and shallow-water octopus, while more oceanic assemblages are largely dominated by ommastrephid and deep-water octopus species. This area shows cephalopod resources that can maintain local and trawl fisheries for these resources, mainly for coastal octopus, neritic loliginids and more pelagic ommastrephids. This work presents a brief review of cephalopod fauna found in CCLME waters in terms of biodiversity, ecology and fisheries. MAVA (Contract 12087 Coastal West Africa C4/2012)