
handle: 10495/5804
RESUMEN: En esta investigación se desarrollaron biomateriales de PVA, CB y nanocompuestos PVA/CB mediante fermentación in situ utilizando una bacteria productora de celulosa Gluconacetobacter medellinensis. Los biomateriales fueron caracterizados mediante microscopía electrónica de barrido (SEM), pruebas de hinchamiento y proliferación celular in-vitro utilizando células de piel humana (Fibroblastos). No se observaron cambios en la morfología celular por el uso de los biomateriales y su microestructura estuvo estrechamente ligada a la proliferación celular. Las células mostraron una mayor afinidad por la CB, resultado relacionado con su similitud en morfología y estructura química con el colágeno. La respuesta obtenida sumada a la capacidad de la CB de imitar la forma de la interfaz gas-líquido durante su síntesis, permitió la construcción de una prenda apósito de CB en forma de guante que podría tener aplicaciones en el tratamiento de quemaduras y úlceras cutáneas.
ABSTRACT: In this research, biomaterials of PVA, CB and in situ fermented PVA/CB nanocomposites were developed, using a cellulose producer bacterium, Gluconacetobacter medellinensis. The biomaterials were characterized through scanning electron microscopy (SEM), swelling and in vitro cell proliferation assay with skin cells (Fibroblast). Changes in the cell morphology were not found by the use of the biomaterials and the cell proliferation is associated with the microstructure of them. Cells showed a higher affinity to CB, outcome related to the morphological and chemical similitudes with collagen. Joining this response with the CB capacity of mimic the gas-liquid interface, was developed a glove shaped wound dressing that will have applications in burn and skin ulcer treatment.
Crecimiento celular, Rrenda apósito, Material nanocompuesto, 610, Celulosa bacteriana, Alcohol polivinílico
Crecimiento celular, Rrenda apósito, Material nanocompuesto, 610, Celulosa bacteriana, Alcohol polivinílico
| selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | 0 | |
| popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network. | Average | |
| influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | Average | |
| impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network. | Average |
