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Manifestaciones bucales en pacientes con Lupus Eritematoso Sistémico

Authors: González Pérez, Leonor Victoria; Rodríguez Padilla, Libia María; Ángel González, Nathaly; Echeverry Muñoz, Natalia; Restrepo Zapata, Ana Paulina;

Manifestaciones bucales en pacientes con Lupus Eritematoso Sistémico

Abstract

RESUMEN: Introducción. El Lupus Eritematoso Sistémico (LES), es una enfermedad autoinmune inflamatoria crónica multisistémica. Los pacientes frecuentemente presentan manifestaciones bucales, lo cual puede ser el primer indicio de la enfermedad. Las lesiones bucales han sido clasificadas como: eritematosas, discoides y de tipo ulcerativo. Este estudio tuvo como objetivo describir las manifestaciones de los tejidos blandos bucales en pacientes con diagnóstico de LES y establecer si existe relación entre estas manifestaciones con el tiempo de diagnóstico de la enfermedad, los marcadores inmunológicos, el compromiso sistémico y el tratamiento farmacológico. Materiales y métodos. Se incluyeron 66 pacientes con diagnóstico de LES; se les realizó un examen estomatológico y se recolectó información demográfica, clínica y de tratamiento por medio de revisión de historias clínicas y una entrevista. A diez pacientes se les realizó análisis citológico para candidiasis. Resultados. 55 pacientes presentaron algún tipo de lesión en cavidad bucal, las cuales fueron: lesiones "sugestivas de candidiasis", en 26 pacientes; petequias, en 23; úlceras, en 17 y queilitis actínica, en 11 pacientes. La candidiasis oral se asoció con el uso de prednisolona; de los 57 pacientes que tomaban este medicamento, 45.6% presentaban lesiones "sugestivas de candidiasis". Sin embargo, no hay asociación entre la dosis exacta de prednisolona y la presencia o ausencia de lesiones. Conclusiones. Los pacientes a quienes se les administra prednisolona, tienen un riesgo de presentar lesiones "sugestivas de candidiasis" 15.98 veces más que los que no la toman. Sin embargo, no se encontró asociación con ningún compromiso sistémico y la presencia de lesiones orales.

ABSTRACT: Objective. Patients with Systemic Lupus Erythematosus (SLE) frequently experience oral manifestations, which can be the first symptom of the disease. Our objective was to describe the manifestations of oral soft tissue in patients diagnosed with SLE, and to establish whether or not there is a relationship between these manifestations and the time at which the disease was diagnosed, the immunological markers, systemic compromise, and pharmacological treatment. Methods. 66 patients diagnosed with SLE were included in the study. Each patient underwent an estomatological examination, and their demographical, clinical, and treatment information was gathered by way of reviewing their clinical history and by participating in an interview. Cytological analysis was performed on ten patients to test for candidiasis. Results. 55 patients presented some type of oral cavity lesion, which included: 26 patients with lesions "suggestive of candidiasis", 23 with petechiae, 17 with ulcers, and 11 with actinic cheilitis. Oral candidiasis was associated with the use of prednisolone. Of the 57 patients who took this medicine, 45.6% had lesions "suggestive of candidiasis". However, there is no association between the presence or absence of lesions and the exact dose of prednisolone taken. Conclusions. Patients taking prednisolone have 15.98 times more probability of suffering lesions "suggestive of candidiasis" than those who do not take this medication. However, no association was found between systemic compromise and the presence of oral lesions.

COL0010959

COL0010074

Country
Colombia
Keywords

Oral, Enfermedades de la Boca, Lupus Erythematosus, Candidiasis, Oral, Lupus Eritematoso Sistémico, Systemic, 616, Candidiasis, 610, Lupus Erythematosus, Systemic, Candidiasis Bucal, Prednisolona

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
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