Factores que afectan la estabilidad de alprazolam. Elucidación estructural de los principales productos de degradación
Copyright policy )Factores que afectan la estabilidad de alprazolam. Elucidación estructural de los principales productos de degradación
RESUMEN: Se ha investigado la influencia de varias condiciones ambientales (temperatura, pH, luz y oxigeno) en la estabilidad de Alprazolam, aplicando técnicas de cromatografía en capa delgada. Se encontró que la luz es el principal factor de degradación del alprazolam. Los principales productos de fotodegradación han sido aislados e identificados por espectroscopia 1H y 13C RMN y espectrometría de masa. Estos productos revelan que en la fotodegradación del alprazolam ocurren reacciones de oxidación, solvólisis y reordenamiento.
ABSTRACT: The influence of various environmental conditions (temperature, pH, light and oxygen) on the stability of Alprazolam has been investigated, applying thin layer chromatography techniques. Light was found to be the main degradation factor for alprazolam. The main photodegradation products have been isolated and identified by 1H and 13C NMR spectroscopy and mass spectrometry. These products reveal that oxidation, solvolysis and rearrangement reactions occur in the photodegradation of alprazolam.
COL0035117
- University of Antioquia Colombia
- Universidad de Antioquia, Sistema de Bibliotecas Colombia
Photolysis, Alprazolam, Fotólisis, http://aims.fao.org/aos/agrovoc/c_28496, TP368-456, 540, Food processing and manufacture, Estabilidad de Medicamentos, Benzodiazepines, Drug Stability, 615, Benzodiazepinas, HD9665-9675, Pharmaceutical industry
Photolysis, Alprazolam, Fotólisis, http://aims.fao.org/aos/agrovoc/c_28496, TP368-456, 540, Food processing and manufacture, Estabilidad de Medicamentos, Benzodiazepines, Drug Stability, 615, Benzodiazepinas, HD9665-9675, Pharmaceutical industry
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