Beta-lactam antibiotics are the most popular antibacterial agents used for treating bacterial infections, due to their great activity, broad spectrum, and safety profile. All of them share the beta-lactam ring and because of the particular chemical structure, they are classified into five groups: Penicillins (natural and semisynthetic), cephalosporins (first-, second-, third-, fourth-, and fifth-generation), monobactams, carbapenems and the association of a beta-lactam with a beta-lactamase inhibitor (Beta-lactam and non-beta-lactam inhibitors). Carbapenems have a carbon atom instead of a sulfur or an oxygen atom in the bicyclic nucleus and a hydroxyethyl side chain in trans configuration at position 6 and are the widest spectrum antibiotics available among the beta-lactams. Beta-lactams are bactericidal agents that kill bacteria by inhibiting the synthesis of the cell wall in both Gram-negative and Gram-positive bacteria, interacting with PBPs, so the transpeptidation reaction is blockaded, leading to the cell lysis and death. As a consequence of the widespread use of this antibiotics, bacterial resistance is a growing problem in both community and hospital settings. Emergence and dissemination of beta-lactam resistance have renewed interest in the development of novel beta-lactam antibiotics or beta-lactamase inhibitors, and some of them are currently available for multi-resistant bacteria treatment