Disgregación/disolución de comprimidos como factores condicionantes de su actividad terapéutica. III. – Comprimidos de Prednisona
Disgregación/disolución de comprimidos como factores condicionantes de su actividad terapéutica. III. – Comprimidos de Prednisona
Se han efectuado estudi'Os de disgregación y disolución "in vitro" en 14 muestras de comprimidos con Prednisolona, prestando especial atención al ensayo de disolución por considerarlo más significativo. Todas las muestras presentan valores aceptables, aunque se acusan diferencias de unas a otras en particular en lo que a disolución se refiere. Se determina la posible correlación entre los parámetros T50 de disolución y Tiempo total de disgregación y se comprueba que existe para 12 de las muestras estudiadas.
Desintegration and dissolution "in vitro" studies have been effected about 14 tablets samples which enclose Prednisolone giving special attention at the dissolution assay for being considered more significative. AH the samples show acceptable values althought differences ave acknowledged among their particulary referring to dissolution. After determining the possible correlation between the dissolution parameter Tso and desintegration total time, the existence of 12 of the studied sampIes are verified.
Extracto de la Tesis Doctoral realizada por D. José Sánchez Morcillo, bajo la dirección de los Profs. Dres. D. José M." Suñé Arbussá y don Antonio Cerezo Galán. Granada, Noviembre de 1973.
- University of Granada Spain
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