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Desarrollo y uso de nanopartículas poliméricas que comprenden poli(epsylon-caprolactona) y doxorrubicina

Authors: Prados Salazar, José Carlos; Aránega Jiménez, Antonia; Melguizo Alonso, Consolación; Ortiz Quesada, Raúl; Ruiz Martínez, Adolfina; Gallardo Lara, Visitación; Arias Mediano, José Luis; +4 Authors

Desarrollo y uso de nanopartículas poliméricas que comprenden poli(epsylon-caprolactona) y doxorrubicina

Abstract

La presente invención se refiere a nanopartículas poliméricas con un tamaño medio inferior a 200 nm, que comprende uno o más polímeros biodegradables, uno o más principios activos y al menos un tensoactivo, donde al menos un polímero biodegradable es poli(ε-caprolactona) y donde al menos un principio activo es doxorrubicina, y al uso de dichas nanopartículas para la preparación de medicamentos para el tratamiento de cáncer, preferiblemente cáncer de mama.

The invention relates to polymer nanoparticles having an average size of less than 200 nm, comprising one or more biodegradable polymers, one or more active principles and at least one surfactant, in which at least one biodegradable polymer is poly(ε-caprolactone) and at least one active principle is doxorubicin. The invention also relates to the use of said nanoparticles for the preparation of drugs for the treatment of cancer, preferably breast cancer.

Número de publicación: ES2386712 B1. Número de solicitud: 201130122.

Servicio Andaluz de Salud

Universidad de Granada

Country
Spain
Related Organizations
Keywords

Nano-biotecnología, Preparaciones medicinales, Compuestos macromoleculares, A61P 35/00, Nanocapsulas, A61K 9/51, B82Y 5/00, A61K 47/34, A61K 31/704

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Related to Research communities
Cancer Research
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