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Propiedades antidiarreicas de Diospyros peregrina en el modelo de diarrea inducida con aceite de ricino en ratones

Authors: Rouf, R.; Uddin, S.J.; Shilpi, J.A.; Toufiiq-Ur-Rahman, M.; Ferdous, M.M.; Sarker, S.D.;

Propiedades antidiarreicas de Diospyros peregrina en el modelo de diarrea inducida con aceite de ricino en ratones

Abstract

Diospyros peregrina (Gruke), de la familia de las ebenáceas, posee varias propiedades medicinales y se utiliza en la medicina tradicional de Bangladesh. En este estudio se investigaron los extractos de metanol de la corteza y las semillas de esta planta en el modelo de diarrea inducida con aceite de ricino en ratones. También se estudiaron las propiedades antibacterianas de los extractos frente a varias bacterias patógenas causantes de diarrea y disentería mediante el método de difusión en disco. Con una dosis de 250 y 500 mg/kg de peso corporal, los extractos retrasaron la aparición de la diarrea. Los extractos también redujeron la frecuencia y la gravedad de la diarrea en los animales de los grupos de prueba durante todo el período de estudio. A igual dosis, los extractos retrasaron el tránsito intestinal del preparado de carbón en los animales del grupo de prueba en comparación con los del grupo de control, y los resultados fueron signifi cativos estadísticamente. En ambos casos, el extracto de semilla resultó más potente que el extracto de corteza. El extracto de corteza inhibió el crecimiento de Staphylococcus aureus, Shigella dysentery, Escherichia coli y Pseudomonas aeruginosa, mientras que el extracto de semilla demostró poseer actividad inhibitoria frente a S. aureus, S. dysentery y E. coli.

Diospyros peregrina Gruke. (Ebenaceae) possesses a number of medicinal properties, and is used in Bangladeshi traditional medicine. In this study, the methanol extracts of the barks and seeds of this plant have been investigated in the castor oil induced diarrhoea model in mice. The extracts were also studied for their anti-bacterial properties by disc diffusion method against a number of pathogenic bacteria responsible for causing diarrhoea and dysentery. At the doses of 250 and 500 mg/kg body weight, the extracts delayed the onset of diarrhoea. The extracts also reduced the frequency and severity of diarrhoea in test animals throughout the study period. At the same doses, the extracts delayed the intestinal transit of charcoal meal in test animals as compared to the control, and the results were statistically signifi cant. In both cases the seed extract was found to be more potent than the bark extract. The bark extract inhibited the growth of Staphylococcus aureus, Shigella dysentery, Escherichia coli and Pseudomonas aeruginosa, whereas the seed extract demonstrated inhibitory activity against S. aureus, S. dysentery and E. coli.

Country
Spain
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Keywords

Ebenaceae, Ebenáceas, Disentería, Diarrea, Medicina tradicional, Traditional Medicine, Diospyros peregrina, Diarrhoea, Dysentery

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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Average
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