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How to assess and interpret phase angle in cancer : the clinical relevance

Authors: Fernandes, Mauro Filipe Gonçalves;

How to assess and interpret phase angle in cancer : the clinical relevance

Abstract

It is widely known that nutritional deterioration in cancer patients is a strong predictor of patients’ treatment outcome and survival. To clarify this association, there is an increasing use of bioelectrical impedance analysis (BIA) to evaluate body composition and phase angle (PhA) in cancer. The aims of this review were: 1) to explore the efficacy of BIA for body composition analysis in cancer; 2) to determine the value of the implementation of BIA for evaluating outcomes in cancer in clinical practice and 3) to evaluate the relevance of assessing phase angle in oncology practice. PubMed, MedLine, CINAHL, EBSCO and Cochrane Library have been searched for relevant publications in English, until March 2017. The keywords used were “cancer”, “phase angle”, “body composition”, “BIA”, “outcomes”. Original research studies were thoroughly reviewed to identify strengths and limitations, to enable a better understanding of the mechanisms and support the use of BIA in the routine evaluation of cancer patients. The use of BIA and its derived parameters, most importantly PhA and body cell mass, provide practitioners with a sensitive, convenient, and non-invasive method for the evaluation of nutritional status, body cell mass and overall health status in cancer patients. BIA can assist practitioners in the evaluation of nutritional deterioration and risk of cachexia. PhA indicates indirectly the integrity of cell membrane, and thus potentially disease progression. The implementation of these parameters given by BIA should be encouraged as they may allow for timely adjustments of treatment regimens, and appropriate nutrition and medical intervention to improve Quality of Life and eventually prognosis.

É globalmente conhecido que a deterioração nutricional em doentes oncológicos é um forte preditor do potencial resultado de um tratamento e de sobrevivência. Para clarificar esta associação, existe um incremento no uso da Análise Bioeléctrica por Bioimpedância (ABB) para avaliar a composição corporal e o ângulo de fase (AF) em oncologia. Os objectivos desta revisão são: 1) determinar o valor da implementação da ABB para avaliar o resultado em oncologia e na prática clínica; 2) determinar a relevância de avaliar o AF na prática clínica em oncologia. PubMed, MedLine, CINAHL, EBSCO e Cochrane foram pesquisadas com o propósito de seleccionar publicações relevantes em Inglês e publicadas até Março de 2017. As palavras chave foram “cancro”, “ângulo de fase”, “composição corporal”, “ABB” e “resultados”. Vários artigos científicos foram completamente revistos como intuíto de identificar os pontos fortes e fracos dos mesmos , para permitir assim uma melhor compreensão dos mecanismos que possam validar o uso de ABB numa avaliação rotineira de doentes oncológicos. O uso de ABB e seus derivados, principalmente o AF e massa celular, fornece aos clínicos um método sensivel, não-invasivo e conveniente para a avaliação nutricional destes doentes. ABB pode assim apoiar os clínicos numa avaliação de uma possível deterioração nutricional e risco de caquéxia. O AF indica inderectamente a integridade da membrana celular e assim possivelmente a progressão da doença. A implementação destes parâmetros deve ser encorajada pois podem permitir ajustes em regimes terapêuticos e aporte nutricional. Promovendo assim uma possível melhor qualidade de vida e prognóstico.

Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2017

Country
Portugal
Related Organizations
Keywords

Análise bioeléctrica por bioimpedância, Domínio/Área Científica::Ciências Médicas, Composição corporal, Nutrição, Ângulo de fase, Cancro

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Green
Related to Research communities
Cancer Research