Accumulating evidence indicates that physically active subject have lower all cause morbidity and mortality than those of sedentary subject. It has been established that low intensity aerobic training improve coronary risk by increasing HDL, HDL2-cholesterol, apolipoprotein-AI and HDL-C/TC, and decreasing triglyceride. Also low intensity training lowers blood pressure and improve insulin resistance. It would be suggested that regular aerobic training may decrease in fibrinogen, platelet aggregation and PAI-1 antigen, and increase in t-PA activity. The low intensity training at 50% VO2max for 60 min/day, 3 times a week can be recommended to exercise therapy in the wide-variety of subjects including coronary heart disease.