Powered by OpenAIRE graph
Found an issue? Give us feedback
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ uBibliorum Repositor...arrow_drop_down
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
versions View all 1 versions
addClaim

Tecido Adiposo como órgão endócrino

O papel das adipocinas e sua relação com o risco cardiovascular
Authors: Barros, Rui Filipe Ribeiro de;

Tecido Adiposo como órgão endócrino

Abstract

Introdução: Nas últimas décadas, a perceção acerca da função do tecido adiposo (TA) tem vindo a mudar, sendo que, atualmente, a gordura já não é considerada apenas como um tecido inerte de armazenamento de energia, mas sim um verdadeiro órgão endócrino, Por um lado, a relação entre gordura e produção de adipocinas prende-se, não com a extensão de gordura corporal, mas com a sua localização. Dentro desta perspetiva, é necessário salientar que a gordura localizada nas vísceras tem um papel fundamental na produção de citocinas. Esta acumulação de gordura visceral induz inflamação crónica, doenças metabólicas e cardiovasculares, incluindo: resistência à insulina, dislipidémias e hipertensão arterial (HTA). Assim, torna-se essencial o estudo do TA como órgão endócrino, de modo a obter a compreensão de como a gordura visceral pode contribuir para o risco cardiovascular (RCV). Material e métodos: Através da base de dados eletrónica Pubmed-Medline, foram selecionados artigos publicados entre 2000 e 2020, em inglês e português, com base nos respetivos títulos e resumo. Os termos de pesquisa utilizados foram: “obesity” AND “metabolic syndrome” AND “cardiovascular risk” AND “adipokines” AND “adipose tissue”. Resultados: A relação entre obesidade, mais concretamente o Tecido adiposo visceral (TAV), e o risco cardiovascular (RCV), ocorre através de efeitos diretos e indiretos sobre o sistema cardiovascular. Não só a desregulação de adipocinas, que causam estados próinflamatórios e contribuem para a resistência à insulina, mas também os efeitos sobre a geometria cardiovascular, contribuem para uma maior mortalidade/morbilidade em indivíduos obesos. Conclusões: O TA, mais especificamente a gordura localizada nas vísceras e a gordura ectópica, devem ser contabilizados como fatores importantes na maior incidência de doenças cardiovasculares na população e, desta forma, deve-se procurar obter uma solução para este problema crescente na sociedade atual.

Introduction: In the last decades, the perception about the function of the adipose tissue (TA) has been changing, being that, nowadays, fat is no longer considered just an inert tissue of energy storage, but a true endocrine organ. On one hand, the relation between fat and the production of adipokines is not just related with the extension of body fat, but also its location. Within this perspective, is necessary pointing out that visceral fat has an important role in adipokines production. This visceral fat accumulation induces chronic inflammation and metabolic diseases including insulin resistance, dyslipidemia, and arterial hypertension (HTA). Thus, it becomes essential the study of the TA as an endocrine organ, so that we can obtain the comprehension of how visceral fat can contribute to the cardiovascular risk (RCV). Material and methods: Through the electronic database Pubmed-Medline, articles published between 2000 and 2020, in English and Portuguese, were selected, based upon the respective titles and abstract. The utilized search terms were: obesity” AND “metabolic syndrome” AND “cardiovascular risk” AND “adipokines” AND “adipose tissue”. Results: The relationship between obesity, more specifically the TAV, and the RCV occurs through direct and indirect effects on the cardiovascular system. Not only the deregulation in the secretion and production of adipokines, that cause proinflammatory states and contribute to insulin resistance, but also the effects on the cardiovascular geometry, add to a bigger mortality/morbidity rate in obese individuals. Conclusions: TA, more specifically the TAV and the ectopic TA, should be accounted as important factors in the elevated incidence of cardiovascular diseases in the population, and, thus, we should look for a solution to this rising problem in today’s society.

Country
Portugal
Related Organizations
Keywords

Domínio/Área Científica::Ciências Médicas::Ciências da Saúde::Medicina, Adipocinas Pró-Inflamatórias, Gordura Visceral, Risco Cardiovascular, Tecido Adiposo

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    0
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
    OpenAIRE UsageCounts
    Usage byUsageCounts
    visibility views 296
    download downloads 378
  • 296
    views
    378
    downloads
    Powered byOpenAIRE UsageCounts
Powered by OpenAIRE graph
Found an issue? Give us feedback
visibility
download
selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
views
OpenAIRE UsageCountsViews provided by UsageCounts
downloads
OpenAIRE UsageCountsDownloads provided by UsageCounts
0
Average
Average
Average
296
378
Green
Related to Research communities