In this article we present some reflections of the ongoing research, developed within the scope of the EEP project — Empowering ePortfolio Process. We discuss some central ideas that emerged from the study focused on the students’ experiences and perspectives of ePortfolios, developed at the School of Education of the Polytechnic Institute of Setubal. We discuss its preliminary results broadening the focus to its implications to Higher Education pedagogy and to the development of students’ transformative capabilities — autonomy, reflexivity, critical thought, creativity and cooperation, amongst others. We highlight the ePortfolio contribution, as an epistemic framework, to the HE pedagogical transformation.