In this work a numerical model, which simulates the buildings thermal response and evaluates the indoor environment comfort, in transient conditions, is used in the application of Heating, Ventilating and Air Conditioning (HVAC) systems control, based in the Predicted Mean Vote (PMV) index, in the energy and thermal comfort performance in a kindergarten school building, in the South of Portugal, in Winter conditions. In the control the PMV index, based in the mean air temperature, the mean air velocity, the mean air relative humidity, the mean radiant temperature, the clothing level and the activity level, are used. In the numerical simulation of the kindergarten, the 25 compartments, the 498 building main bodies and the 42 windows glasses, as well as two schools and three residential surrounding main buildings, are considered.