Enhancement of (-)-stepholidine on protein phosphorylation of a dopamine- and cAMP-regulated phosphoprotein in denervated striatum of oxidopamine-lesioned rats.
Copyright policy )Enhancement of (-)-stepholidine on protein phosphorylation of a dopamine- and cAMP-regulated phosphoprotein in denervated striatum of oxidopamine-lesioned rats.
To study effects of (-)-stepholidine (SPD) on the phosphorylation of a dopamine- and cAMP-regulated phosphoprotein (DARPP-32) in the striatum of oxidopamine-lesioned rats.The amount of dephospho-DARPP-32 was measured by a back-phosphorylation assay.In the striatum of control rats, SPD per se had no effect on the phosphorylation of DARPP-32, but it antagonized the decrease by 28% of dephospho-DARPP-32 induced by the D1 agonist SK&F-38393. In the denervated striatum of oxidopamine-lesioned rats, SPD decreased the amount of dephospho-DARPP-32 by 44%. The effect of SPD was completely counteracted by the concomitant administration of the D1 antagonist Sch-23390.SPD exhibits D1 agonistic action on DARPP-32 phosphorylation in the denervated striatum of oxidopamine-lesioned rats, but it acts as a D1 antagonist in normal striatum.
- Chinese Academy of Sciences China (People's Republic of)
- Shanghai Institute of Materia Medica China (People's Republic of)
Male, Dopamine and cAMP-Regulated Phosphoprotein 32, Berberine, Nerve Tissue Proteins, Benzazepines, Phosphoproteins, Corpus Striatum, Rats, Rats, Sprague-Dawley, Dopamine Agonists, Animals, Dopamine Antagonists, 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine, Enzyme Inhibitors, Phosphorylation, Oxidopamine
Male, Dopamine and cAMP-Regulated Phosphoprotein 32, Berberine, Nerve Tissue Proteins, Benzazepines, Phosphoproteins, Corpus Striatum, Rats, Rats, Sprague-Dawley, Dopamine Agonists, Animals, Dopamine Antagonists, 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine, Enzyme Inhibitors, Phosphorylation, Oxidopamine
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