La epidemia de la viruela represent? para la Corona espa?ola un asunto de salud de gran importancia por lo que organiz? la primera campa?a de vacunaci?n en sus posesiones en Nueva Espa?a y Asia. El descubrimiento de la vacuna por parte del Dr. Jenner, impuls? al Dr. Francisco Xavier Balmis a realizar la que es considerada hoy, la primera misi?n de cooperaci?n internacional. Su traves?a a lo largo de las colonias en compa??a de Isabel de Cendala y 22 ni?os portadores de la linfa de la viruela son protagonistas de la pel?cula.

The smallpox epidemic represented a health issue of great importance for the Spanish Crown, reason for which it organized the first vaccination campaign in all its possessions in New Spain and Asia. The discovery of the vaccine by Dr. Jenner prompted Dr. Francisco Xavier Balmis to carry out what is considered nowadays the first international cooperation mission. His journey through the colonies with the company of Isabel de Cendala and 22 children, all of them are the protagonists of this film.