[ES]Las fluoroquinolonas son agentes bactericidas de amplio espectro indicadas para el tratamiento de m?ltiples patolog?as infecciosas. Los liposomas constituyen excelentes veh?culos farmacol?gicos capaces de modular el perfil de liberaci?n del principio activo encapsulado. La alb?mina presenta elevada capacidad de uni?n y transporte de solutos. El objetivo del presente estudio ha sido incorporar ciprofloxacino a formulaciones basadas en la combinaci?n de liposomas y alb?mina para aunar las ventajas de ambos en un veh?culo farmac?utico. La preparaci?n de los liposomas se llev? a cabo mediante sonicaci?n en ausencia de disolventes org?nicos, empleando distintas disoluciones de ciprofloxacino. Para la formaci?n de los albusomas se emple? alb?mina s?rica bovina. Se evalu? la influencia de tres variables en la eficacia de encapsulaci?n: presencia o ausencia de componentes cati?nicos en los liposomas, concentraci?n de ciprofloxacino y concentraci?n de alb?mina; se cuantific? el antibi?tico mediante una t?cnica de HPLC. Los resultados obtenidos indican que la composici?n de los liposomas influye significativamente sobre la eficacia de encapsulaci?n obtenida y que la concentraci?n de ciprofloxacino no afecta a este par?metro.

[EN]Fluoroquinolones are bactericidal agents showing a broad antimicrobial spectrum used for several infectious diseases. Liposomes are excellent carriers for controlled drug delivery and albumin shows a great capacity for binding and transport of solutes. The aim of this study was to incorporate ciprofloxacin into a formulation based on the combination of liposomes and albumin in order to gather the advantages of both components into a single pharmaceutical vehicle. Liposomes were prepared by sonication, in absence of organic solvents, by using ciprofloxacin solutions of different concentration. The albusomes were prepared by mixing these with bovine serum albumin. The influence of three variables on the drug encapsulation efficiency was evaluated: liposomes composition, ciprofloxacin concentration and albumin amount; an HPLC technique was used for drug quantification. The results of the study reveal that liposomes composition significantly affects the entrapment efficiency registered while ciprofloxacin concentration does not affect this parameter.