Evaluation of anti-tumor efficacy of injectable Centchroman in mice bearing Ehrlich ascites carcinoma.
Copyright policy )Evaluation of anti-tumor efficacy of injectable Centchroman in mice bearing Ehrlich ascites carcinoma.
Anti-tumor efficacy of Centchroman formulated as niosomes and gel implant was evaluated in Swiss albino mice bearing Ehrlich ascites carcinoma at 10 mg/kg body weight dose given subcutaneously. Median day of death, percentage increase in host life span and changes in body weight were studied. Centchroman significantly (P < 0.05) increased the median day of death both in free and formulated systems. Also, injectable formulations exhibited a significant (P < 0.05) increase in host life span compared to free drug, hence, enhanced anti-tumor efficacy against Ehrlich ascites carcinoma.
Centchroman, Mice, Chemistry, Pharmaceutical, Body Weight, Animals, Antineoplastic Agents, Drug Screening Assays, Antitumor, Carcinoma, Ehrlich Tumor
Centchroman, Mice, Chemistry, Pharmaceutical, Body Weight, Animals, Antineoplastic Agents, Drug Screening Assays, Antitumor, Carcinoma, Ehrlich Tumor
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