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Bachelor thesis . 2020
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Bachelor thesis . 2020
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Desarrollo de Antagonistas selectivos del receptor A3 de Adenosina

Development of adenosine A3 receptor selective antagonists
descriptionPublicationkeyboard_double_arrow_right Bachelor thesis 01 Jan 2020 Spain Spanish
Authors: Miranda Pastoriza, Darío;

handle: 10347/23733

Desarrollo de Antagonistas selectivos del receptor A3 de Adenosina

Abstract

El presente Trabajo de Fin de Grado describe el diseño, síntesis y evaluación farmacológica de derivados del sistema 1,4-dihidrobenzo[4,5]imidazo[1,2-a]pirimidina como antagonistas del receptor A3 de adenosina. Empleando una variante de la reacción de Biginelli se obtuvo una colección de 19 ligandos. Uno de los compuestos sintetizados mostró una elevada afinidad (Ki=2.28 nM) por el receptor A3 de adenosina

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
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Average
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