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BOA - Bicocca Open Archive
Patent . 2012
Full-Text: https://boa.unimib.it/bitstream/10281/68196/2/US20130041013.pdf
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Patent . 2008
Full-Text: https://boa.unimib.it/bitstream/10281/61781/6/US20100081704.pdf
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Isoform of Bruton's tyrosine kinase (BTK) protein

descriptionPublicationkeyboard_double_arrow_right Patent 14 Mar 2008 English
Authors: LAVITRANO, MARIALUISA; GRASSILLI, EMANUELA; Helin, K.;

handle: 10281/68196 , 10281/61781

Isoform of Bruton's tyrosine kinase (BTK) protein

Abstract

The use of compounds is described which are capable of functionally blocking at least one of the genes chosen from the group composed of EphA1, EphA2, EphA8, EphB2, CSF1R, VEGFR2, RAMP2, RAMP3, CLRN1, MAPK4, PIK3C2A, PIK3CG, GSK3alpha, GSK3beta, IRAK3, DAPK1, JAK1, PIM1, TRB3, BTG1, LATS1, LIMK2, MYLK, PAK1, PAK2, CDC2, BTK, PNRC2, NCOA4, NR2C1, TPR, RBBP8, TRPC7, FXYD1, ERN1, PRSS16, RPS3, CCL23 and SERPINE1, for the manufacture of a medicament destined to diminish the resistance to chemotherapeutic drugs in the therapeutic treatment of epithelial tumor pathologies. Also described is a method for the determination of the drug resistance in tumor cells, as well as a method for the identification of tumor stem cells

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Keywords

siRNA, drug resistance, epithelial tumors, siRNA; drug resistance; colon cancer

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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