Activities of Polymyxin B and Cecropin A-Melittin Peptide CA(1-8)M(1-18) against a Multiresistant Strain of  Acinetobacter baumannii

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 2002 English Publisher:American Society for MicrobiologyJournal:Antimicrobial Agents and Chemotherapy, volume 46, pages 875-878 (issn: 0066-4804, eissn: 1098-6596,

Copyright policy )

Authors: Saugar, José María; Alarcón, Teresa; López-Hernández, Susana; López-Brea, Manuel; Andreu, David; Rivas, Luis;

doi: 10.1128/aac.46.3.875-878.2002

pmid: 11850277

pmc: PMC127505

handle: 10261/97097

Activities of Polymyxin B and Cecropin A-Melittin Peptide CA(1-8)M(1-18) against a Multiresistant Strain of Acinetobacter baumannii

- Summary
- Subjects
- Metrics

Abstract

ABSTRACT Polymyxin B (PXB) and the cecropin A-melittin hybrid CA(1-8)M(1-18) (KWKLFKKIGIGAVLKVLTTGLPALIS-NH 2 ) were compared for antibiotic activity on reference and multiresistant Acinetobacter baumannii strains. Significant differences for both peptides were observed on their inner membrane interaction and inhibition by environmental factors, supporting the use of CA(1-8)M(1-18) as a potential alternative to PXB against Acinetobacter .

Related Organizations

Spanish National Research Council
Spain
University of Barcelona
Spain
Hospital Universitario de La Princesa
Spain
Comunidad de Madrid
Spain

Keywords

Cross Infection, Membranes, Acinetobacter, Molecular Sequence Data, Colony Count, Microbial, Drug Resistance, Microbial, Microbial Sensitivity Tests, Melitten, Anti-Bacterial Agents, Oxygen Consumption, Humans, Amino Acid Sequence, Antimicrobial Cationic Peptides, Bacterial Outer Membrane Proteins, Polymyxin B

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	52
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%