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Recolector de Ciencia Abierta, RECOLECTA
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idUS. Depósito de Investigación de la Universidad de Sevilla.
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Claim

Antimalarial activity of cupredoxins: the interaction of Plasmodium Merozoite Surface Protein 119 (MSP119) and Rusticyanin

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2013 Spain English Publisher:American Society for Biochemistry & Molecular Biology (ASBMB)
Authors: Cruz Gallardo, Isabel; Díaz Moreno, Irene; Díaz Quintana, Antonio Jesús; Velázquez Campoy, Adrián; Curd, Rachel D.; Rangachari, Caveri; Bridsall, Berry; +3 Authors

handle: 10261/95459 , 11441/70218

Antimalarial activity of cupredoxins: the interaction of Plasmodium Merozoite Surface Protein 119 (MSP119) and Rusticyanin

Abstract

Background: The interaction of MSP119 with the cupredoxin azurin inhibits the growth of Plasmodium falciparum in red blood cells. Results: Rusticyanin forms a well-defined complex with MSP119 upon binding at the same surface area than inhibitory antibodies. Conclusion: Rusticyanin becomes an excellent therapeutic agent for malaria. Significance: Knowing the rusticyanin- MSP119 interface will allow the design of novel anti-malarial drugs

Ministerio de Economía y Competitividad SAF2011- 26611

Fundación Séneca de la Región de Murcia 15354/PI/10

Ministerio de Ciencia e Innovación BFU2010-19451

Medical Research Council U117574558, U117532067

Junta de Andalucía P08-CVI-3876, BIO198

Country
Spain
Related Organizations
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Keywords

Rustycianin, Plamodium, MSP1, ITC, NMR, Malaria

  • BIP!
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    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Green