Synthesis and preliminary antifungal evaluation of a library of phytosphingolipid analogues

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2007 English Publisher:Royal Society of Chemistry (RSC)Journal:Organic & Biomolecular Chemistry, volume 5, page 3,769 (issn: 1477-0520, eissn: 1477-0539,

Copyright policy )

Authors: Mormeneo, David; Casas, Josefina; Llebaria, Amadeu; Delgado Cirilo, Antonio;

doi: 10.1039/b709421c

pmid: 18004456

handle: 10261/9507

Synthesis and preliminary antifungal evaluation of a library of phytosphingolipid analogues

- Summary
- Subjects
- Metrics

Abstract

A library of 64 phytosphingolipid analogues resulting from the systematic variation of the C1, C3, C4, and the N-acyl moiety of phytosphingosine (PHS) has been prepared from common scaffolds derived from the chiral pool and Sharpless asymmetric dihydroxylation reactions. Library members have been evaluated as growth inhibitors of the yeast Saccaromyces cerevisiae. In addition, 1-amino-N-pivaloyl PHS analogues were also tested as IPC synthase inhibitors, in comparison with the natural product khafrefungin.

Related Organizations

University of Barcelona
Spain

Keywords

Spectrometry, Mass, Electrospray Ionization, Sphingolipids, Antifungal Agents, Magnetic Resonance Spectroscopy, Yeast Saccaromyces cerevisiae, Antifungal evaluation, Saccharomyces cerevisiae, Phytosphingolipid analogues, Growth inhibitors

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	13
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%