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Uso de secuencias nucleotídicas que codifican pirofosfatasas translocadoras de protones para producir levaduras, hongos y células animales resistentes a fármacos citotóxicos y fungicidas y método para producirlas

Authors: Serrano, Aurelio; Hernández, Agustín; Pérez-Castiñeira, J. R.;

Uso de secuencias nucleotídicas que codifican pirofosfatasas translocadoras de protones para producir levaduras, hongos y células animales resistentes a fármacos citotóxicos y fungicidas y método para producirlas

Abstract

La presente invención se refiere a una secuencia de nucleótidos de origen vegetal o microbiano que codifica para una secuencia de aminoácidos correspondiente a una pirofosfatasa translocadora de protones (H+-PPasa, miembro de una familia de proteínas con código identificativo PF03030 de la base de datos Pfam), la cual es usada para transformar o transfectar una célula de levadura (p.e. Saccharomyces cerevisiae), fúngica o animal que naturalmente no contienen esta clase de proteínas, con la finalidad de producir resistencia a fármacos o antibióticos citotóxicos y a fungicidas.

Consejo Superior de Investigaciones Científicas (España), Universidad de Sevilla

A1 Solicitud de patente con informe sobre el estado de la técnica

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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