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handle: 10261/93073
[ES] En la presente invención se describe el diseño y realización de un procedimiento para facilitar la producción de sustancias, y en particular de polihidroxialcanoatos (PHAs) en Pseudomonas putida a partir de glicerol. A tal fin se ha construido una cepa mutante derivada de P.putida portadora de una mutación en el cromosoma del gen glpR que permite que la bacteria pueda utilizar el glicerol como fuente de carbono y energía de una manera más eficiente y por lo tanto permite mejorar la producción de biomasa y de sustancias a partir de glicerol como por ejemplo mejorar la producción de los gránulos de PHA reduciendo a la mitad el tiempo de producción.
[EN] The present invention relates to the development and execution of a method for facilitating the production of substances, in particular polyhydroxyalkanoates (PHAs), in Pseudomonas putida from glycerol. For said purpose, a mutant strain derived from P. putida has been constructed which comprises a mutation in the chromosome of the glpR gene that enables the bacteria to use glycerol as a source of carbon and energy in a more efficient manner, and thus makes it possible to improve the production of biomass and substances from glycerol, such as, for example, improving the production of PHA granules by halving the production time thereof.
A1 Solicitud de patente con informe sobre el estado de la técnica
Consejo Superior de Investigaciones Científicas (España)
Peer reviewed
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