Novel hydrogels of chitosan and poly(vinyl alcohol)-g-glycolic acid copolymer with enhanced rheological properties

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 2014 English Publisher:Elsevier BVJournal:Carbohydrate Polymers, volume 103, pages 267-273 (issn: 0144-8617,

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Authors: Lejardi, A.; Hernández, R.; Criado, María; Santos, J. Ignacio; Etxeberría, A.; Sarasua, J. R.; Mijangos, Carmen;

doi: 10.1016/j.carbpol.2013.12.040

pmid: 24528729

handle: 10261/93000

Novel hydrogels of chitosan and poly(vinyl alcohol)-g-glycolic acid copolymer with enhanced rheological properties

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Abstract

Poly(vinyl alcohol) (PVA) has been grafted with glycolic acid (GL), a biodegradable hydroxyl acid to yield modified poly(vinyl alcohol) (PVAGL). The formation of hydrogels at pH = 6.8 and physiological temperature through blending chitosan (CS) and PVAGL at different concentrations has been investigated. FTIR, DOSY NMR and oscillatory rheology measurements have been carried out on CS/PVAGL hydrogels and the results have been compared to those obtained for CS/PVA hydrogels prepared under the same conditions. The experimental results point to an increase in the number of interactions between chitosan and PVAGL in polymer hydrogels prepared with modified PVA. The resulting materials with enhanced elastic properties and thixotropic behavior are potential candidates to be employed as injectable materials for biomedical applications.

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Keywords

Chitosan, Polyvinyl Alcohol, Hydrogels, Rheology, Glycolates

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