Genome-wide analysis reveals that Smad3 and JMJD3 HDM co-activate the neural developmental program

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 2012 English Publisher:The Company of BiologistsJournal:Development, volume 139, pages 2,681-2,691 (issn: 0950-1991, eissn: 1477-9129,

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Authors: Estarás, Conchi; Akizu, Naiara; García, Alejandra; Beltrán, Sergi; Cruz, Xavier de la; Martínez-Balbás, Marian;

doi: 10.1242/dev.078345

pmid: 22782721

handle: 10261/87875

Genome-wide analysis reveals that Smad3 and JMJD3 HDM co-activate the neural developmental program

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Abstract

Neural development requires crosstalk between signaling pathways and chromatin. In this study, we demonstrate that neurogenesis is promoted by an interplay between the TGFβ pathway and the H3K27me3 histone demethylase (HDM) JMJD3. Genome-wide analysis showed that JMJD3 is targeted to gene promoters by Smad3 in neural stem cells (NSCs) and is essential to activate TGFβ-responsive genes. In vivo experiments in chick spinal cord revealed that the generation of neurons promoted by Smad3 is dependent on JMJD3 HDM activity. Overall, these findings indicate that JMJD3 function is required for the TGFβ developmental program to proceed.

Related Organizations

Spanish National Research Council
Spain
Molecular Biology Institute of Barcelona
Spain
University of Barcelona
Spain

Keywords

Neurons, Jumonji Domain-Containing Histone Demethylases, JMJD3 (Kdm6b), Histone demethylation, Neurogenesis, Green Fluorescent Proteins, TGFβ pathway, Chick Embryo, Models, Biological, Epigenetic regulation, Mice, HEK293 Cells, Gene Expression Regulation, Spinal Cord, Transforming Growth Factor beta, Animals, Humans, Smad3 Protein, Phosphorylation, Smad3, Developmental Biology, Genome-Wide Association Study, Oligonucleotide Array Sequence Analysis

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