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Revista de Neurología
Article . 2002 . Peer-reviewed
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Trauma en el sistema nervioso central y su reparación

Authors: Nieto-Sampedro, Manuel; Collazos-Castro, J. E.; Taylor, Julian S.; Gudiño-Cabrera, G.; Verdú-Navarro, Enrique; Pascual-Piédrola, J. I.; Insausti-Serrano, R.;

Trauma en el sistema nervioso central y su reparación

Abstract

[ES]Desarrollo. Las lesiones de cerebro y médula espinal están adquiriendo una creciente importancia social y económica. En los países desarrollados, el trauma accidental es la causa principal de la muerte de niños y adultos jóvenes. Solamente las enfermedades cardíacas y el cáncer superan a los accidentes como causa de mortalidad y, si examinamos los años de trabajo potencial perdidos, las lesiones del sistema nervioso central (SNC) superan a todos los demás problemas. La mayoría de las lesiones de cerebro y médula espinal ocurren en individuos menores de 45 años de edad y causan incapacidad crónica. El edema y otros fenómenos de fase aguda pueden tratarse eficazmente y las lesiones del SNC no son mortales, pero sí incurables. Conclusión. Las consecuencias finales de una lesión del SNC dependen del lugar dañado y la magnitud de la lesión; lo mejor que las terapias actuales pueden ofrecer es alivio de los síntomas y rehabilitación. Esta revisión examina el estado actual de la reparación funcional de lesiones experimentales traumáticas del sistema nervioso central.

[EN]Development. Brain and spinal cord lesions have an increasing social and economic importance. Accidental trauma of various kinds is the main cause of mortality of children and young adults in developed countries. Only cardiac disease and cancer surpass the number of death caused by accidents and, examining the number of potential work-years lost, CNS lesions surpass all other problems. Most brain and spinal cord injuries cause chronic incapacity and frequently occur to individuals under 45 years of age. Edema and other acute events can be efficiently treated and CNS lesions may not be mortal, but are incurable. Conclusion. The final outcome of CNS injury depend on the area damaged and the extent of the lesion, but the best present therapies can offer is relief of the symptoms and rehabilitation. This review examines the present state of functional repair of experimental central nervous system trauma.

El trabajo de nuestro equipo ha sido financiado por el CSIC, el FIS, la CICYT y la Unión Europea.

Peer reviewed

Keywords

Lesion repair, Spinal cord, Injuries, Visceral function, Cerebro, Función visceral, Neuronal death, Voluntary movement, Recuperación funcional, Brain, Injury, Function recovery, Trauma, Médula espinal, Recuperación sensorimotora, Locomoción, Muerte neuronal, Movimiento voluntario, Reparación de lesiones, Locomotion, Sensorimotor recovery, Lesión, Traumatismo

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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