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Método de diagnóstico de la enfermedad de Alzheimer que emplea SFRP1 como biomarcador

Authors: Bovolenta, Paola; Esteve, Pilar; Sandonis Consuegra, África; Crespo Galán, Inmaculada; Guerrero Vega, Isabel; Ibáñez Pérez, Carmen; Arribas, Joaquín; +2 Authors

Método de diagnóstico de la enfermedad de Alzheimer que emplea SFRP1 como biomarcador

Abstract

La presente invención se refiere a un método de diagnóstico de la enfermedad de Alzheimer que comprende (a) detectar y/o cuantificar el producto de expresión de una secuencia nucleotídica de un gen sfrp1 en una muestra aislada; (b) comparar la cantidad detectada y/o cuantificada con una cantidad de referencia; (c) identificar cualquier desviación significativa en la comparación de datos de la etapa (b); y, (d) atribuir la desviación significativa identificada a la presencia de la enfermedad de Alzheimer. Así mismo, la presente invención se refiere al uso de un kit que comprende cebadores y/o sondas que hibridan con la secuencia nucleotídica de un gen sfrp1 o anticuerpos que se unen específicamente a una secuencia aminoacídica codificada por la secuencia nucleotídica de un gen sfrp1 para determinar la presencia de una enfermedad de Alzheimer.

Consejo Superior de Investigaciones Científicas, Vall D'hebron Institut de Recerca, Vall D'hebron Institute of Oncology, Institució Catalana de Recerca I Estudis Avançats, National University of Singapore

A1 Solicitud de patente con informe sobre el estado de la técnica

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Green