A single icv injection of KCl induces a selective and long-lasting inhibition of opioid analgesia in mice.

The icv administration of potassium chloride a few min before the icv injection of opioids, antagonized the supraspinal analgesia induced by these substances in the mouse. The antagonistic effect of a single injection of KCl lasted for 3 to 4 days and was accompanied by opposite changes in 3H-DADLE binding to mesencephalic (decrease) and spinal cord (increase) membranes.

Peer Reviewed

Country

Spain

Related Organizations

Spanish National Research Council
Spain
Cajal Institute
Spain

Keywords

Narcotics, Mice, Structure-Activity Relationship, Receptors, Opioid, Animals, Enkephalins, Analgesia, Sodium Chloride, Cerebral Ventricles, Injections, Intraventricular, Potassium Chloride

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