Brain steroidogenesis: emerging therapeutic strategies to prevent neurodegeneration

descriptionPublicationkeyboard_double_arrow_right Article 30 Jun 2004 English Publisher:Springer Science and Business Media LLCJournal:Journal of Neural Transmission, volume 112, pages 171-176 (issn: 0300-9564, eissn: 1435-1463,

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Authors: Azcoitia, I.; Sierra, Amanda; Veiga, Sergio; García-Segura, Luis M.;

doi: 10.1007/s00702-004-0179-y

pmid: 15599615

handle: 10261/71830

Brain steroidogenesis: emerging therapeutic strategies to prevent neurodegeneration

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Abstract

Decreasing levels of gonadal steroids with aging are associated to an increase in cognitive, neurological and psychiatric disturbances. Estradiol is neuroprotective in animal models of neurodegeneration. However, the effects of hormonal replacement therapy on brain function in postmenopausal women are controversial. A possible alternative to hormonal replacement therapy is to increase local brain steroidogenesis, since experimental studies indicate that local estrogen formation in the brain is neuroprotective.

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Keywords

Hormone Replacement Therapy, Nerve Degeneration, Animals, Brain, Humans, Steroids

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