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handle: 10261/6891
Polipéptido de ADN polimerasa lambda (Pol lambda) aislado que comprende una secuencia de aminoácidos tal y como se establece en la SEC ID No: 5. La presente invención se refiere a la identificación y aislamiento de una ADN polimerasa y las utilizaciones de esta polimerasa. En particular, la presente invención describe la secuencia nucleotídica del gen humano para la ADN polimerasa lambda (Pol ), la secuencia de aminoácidos de Pol , y la secuencia de aminoácidos de varias isoformas derivadas del splicing alternativo de su ARNm. La asociación de varias de estas isoformas con muestras tumorales hace que el Pol sea un marcador de diagnóstico, pronóstico y evolución de procesos tumorales.
Traducción de Patente Europea E00964482 (fecha de solicitud, 02/10/2000).-- Prioridad: ES199910019902169.-- Titular: Consejo Superior de Investigaciones Científicas (CSIC).
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