Antidepressive and anxiolytic activity of selective estrogen receptor modulators in ovariectomized mice submitted to chronic unpredictable stress

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 2012 English Publisher:Elsevier BVJournal:Behavioural Brain Research, volume 227, pages 287-290 (issn: 0166-4328,

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Authors: Calmarza-Font, Isabel; Lagunas, Natalia; García-Segura, Luis M.;

doi: 10.1016/j.bbr.2011.10.036

pmid: 22061801

handle: 10261/61240

Antidepressive and anxiolytic activity of selective estrogen receptor modulators in ovariectomized mice submitted to chronic unpredictable stress

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Abstract

Estradiol has antidepressive and anxiolytic actions. However, its therapeutic use is limited by its peripheral effects. Selective estrogen receptor modulators may represent an alternative to estradiol for the treatment of depressive symptoms. Here we report that tamoxifen and raloxifene decrease immobility time in the forced swim test and increases the time spent in open arms in the elevated plus maze in ovariectomized mice submitted to chronic unpredictable stress.

Related Organizations

Spanish National Research Council
Spain
Cajal Institute
Spain

Keywords

Selective Estrogen Receptor Modulators, Depression, Ovariectomy, Immobility Response, Tonic, Anxiety, Disease Models, Animal, Mice, Tamoxifen, Social Isolation, Raloxifene Hydrochloride, Animals, Female, Maze Learning, Stress, Psychological, Swimming

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