Liver function tests and absolute lymphocyte count at day +100 are predictive factors for extensive and severe chronic graft‐versus‐host disease after allogeneic peripheral blood stem cell transplant

descriptionPublicationkeyboard_double_arrow_right Article 16 Feb 2010 Spain English Publisher:WileyJournal:American Journal of Hematology, volume 85, pages 290-293 (issn: 0361-8609, eissn: 1096-8652,

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Authors: Silva, Fernando; Pérez-Simón, José A.; Caballero-Velázquez, Teresa; Encinas, Cristina; Sánchez-Guijo, Fermín M.; Díez-Campelo, María; Colado, Enrique; +6 Authors

doi: 10.1002/ajh.21613

pmid: 20162543

handle: 10261/61091

Liver function tests and absolute lymphocyte count at day +100 are predictive factors for extensive and severe chronic graft‐versus‐host disease after allogeneic peripheral blood stem cell transplant

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Abstract

Chronic graft-versus-host disease (cGVHD) is the major late complication after allogeneic hematopoietic stem cell transplant [1,2]. In this article, we have analyzed the value of noninvasive day 1100 tests as predictors of severe cGVHD development in 165 patients undergoing allogeneic peripheral blood stem cell transplant (allo-PBSCT) from a matched related donor. The cumulative incidence of overall, extensive, and severe cGVHD was 67, 56, and 23%, respectively, among patients surviving >100 days after transplant. In univariate analysis, patients displaying an abnormal liver function tests (LFTs) (total bilirubin, alkaline phosphatase, and GGT > 2 times above the upper normal limit) and a low absolute lymphocyte count (ALC) (

Peer Reviewed

Country

Spain

Related Organizations

University of Salamanca
Spain
Spanish National Research Council
Spain

Keywords

Adult, Male, Peripheral Blood Stem Cell Transplantation, Adolescent, Graft vs Host Disease, Bilirubin, gamma-Glutamyltransferase, Middle Aged, Alkaline Phosphatase, Severity of Illness Index, Young Adult, Liver Function Tests, Predictive Value of Tests, Risk Factors, Chronic Disease, Humans, Female, Lymphocyte Count, Aged

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