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Use of dlkl as an angiogenesis inhibitor

Authors: Lamas Peláez, Santiago; Rodríguez, Patricia; Higueras López, M. Ángeles; Laborda, Jorge;

Use of dlkl as an angiogenesis inhibitor

Abstract

[ES] La presente invención se refiere ai uso de de una construcción génica que comprende una secuencia codificante de Dlkl o la proteina recombinante que resulta de la expresión de dicha construcción génica para la preparación de un medicamento para la inhibición de la angiogénesis, preferentemente la angiogénesis tumoral. También forma parte de la invención el uso de un producto de la expresión de Dlkl o de cualquiera de sus fragmentos como biomarcador para la determinación de la angiogénesis o de su progresión. Así mismo, también se refiere a un método de determinación de angiogénesis patológica o de su progresión. También se refiere al uso de un kit que comprende la secuencia que codifica para dlkl o cualquiera de sus productos de expresión para el diagnóstico de angiogénesis patológica.

[EN] The invention relates to the use of a gene construction comprising a sequence encoding Dlkl or the recombinant protein resulting from the expression of said gene construction for the preparation of a medicament for inhibiting angiogenesis, preferably tumoral angiogenesis. The invention also relates to the use of a product of the expression of Dlkl or any of its fragments as a biomarker for detennining angiogenesis or the progression thereof. The invention further relates to a method for detennining pathological angiogenesis or the progression thereof, and to the use of a kit comprising the sequence encoding for dlkl or any of its expression products for the diagnosis of pathological angiogenesis.

Consejo Superior de Investigaciones Científicas (España), Universidad de Castilla la Mancha.

A2 Solicitud de patente sin informe sobre el estado de la técnica

Peer reviewed

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Green
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