Downloads provided by UsageCountsRole of Klebsiella pneumoniae OmpK35 Porin in Antimicrobial Resistance
Copyright policy ) Doménech-Sánchez, Antonio; Martínez-Martínez, Luis; Hernández-Allés, Santiago; Conejo, María del Carmen; Pascual, Álvaro; Tomás, Juan M.; Albertí, Sebastián; +1 Authors
Doménech-Sánchez, Antonio; Martínez-Martínez, Luis; Hernández-Allés, Santiago; Conejo, María del Carmen; Pascual, Álvaro; Tomás, Juan M.; Albertí, Sebastián; Benedí Benito, Vicente Javier;
Role of Klebsiella pneumoniae OmpK35 Porin in Antimicrobial Resistance
ABSTRACT OmpK35 from Klebsiella pneumoniae is the homologue of Escherichia coli OmpF porin. Expression of OmpK35 in K. pneumoniae strain CSUB10R (lacking both OmpK35 and OmpK36) decreased the MICs of cephalosporins and meropenem ≥128-fold and decreased the MICs of imipenem, ciprofloxacin, and chloramphenicol ≥8-fold. MIC reductions by OmpK35 were 4 times (cefepime), 8 times (cefotetan, cefotaxime, and cefpirome), or 128 times (ceftazidime) higher than those caused by OmpK36, but the MICs were similar or 1 dilution lower for other evaluated agents.
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Sequence Homology, Amino Acid, Molecular Sequence Data, Porins, Microbial Sensitivity Tests, Protein Structure, Secondary, Klebsiella pneumoniae, Anti-Infective Agents, Bacterial Proteins, Drug Resistance, Bacterial, Amino Acid Sequence, Sequence Alignment
Sequence Homology, Amino Acid, Molecular Sequence Data, Porins, Microbial Sensitivity Tests, Protein Structure, Secondary, Klebsiella pneumoniae, Anti-Infective Agents, Bacterial Proteins, Drug Resistance, Bacterial, Amino Acid Sequence, Sequence Alignment
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).144 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10% views 41 downloads 29 - 41views29downloads
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This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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