
handle: 10261/50348
La invención se relaciona con variantes del dominio Nterminal de activación de transcripción de p300 que presentan mutaciones en los sitios de fosforilación dando lugar a mutantes no fosforilables y que carecen de actividad transcripcional o de mutantes que mimetizan restos residuos fosforilados dando lugar a variantes constitutivamente activas de p300. Las variantes de p300 se pueden utilizar para el tratamiento de enfermedades tales como cáncer, enfermedades autoinmunes, infecciones, etc.
A1 Solicitud de patente con informe sobre el estado de la técnica
Consejo Superior de Investigaciones Científicas (España)
Peer reviewed
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