<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=undefined&type=result"></script>');
-->
</script>

COPY SCRIPT

For further information contact us at helpdesk@openaire.eu

Synthesis and structural properties of oligonucleotides covalently linked to acridine and quindoline derivatives through a threoninol linker

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 2010 Italy, Spain English Publisher:Elsevier BVJournal:Bioorganic & Medicinal Chemistry, volume 18, pages 7,348-7,356 (issn: 0968-0896,

Authors: A. Aviñó; S. Mazzini; R. Ferreira; R. Eritja;

doi: 10.1016/j.bmc.2010.09.023

pmid: 20888244

handle: 10261/46951 , 2434/154779

Synthesis and structural properties of oligonucleotides covalently linked to acridine and quindoline derivatives through a threoninol linker

- Summary
- Subjects
- Related research
  (11)
- Metrics

Abstract

Oligonucleotide conjugates containing acridine and quindoline derivatives linked through a threoninol molecule were synthesized. We showed that these conjugates formed duplexes and quadruplexes with higher thermal stability than the corresponding unmodified oligonucleotides. When acridine is located in the middle of the sequence, DNA duplexes have a similar stability independently of the natural base present in front of acridine. Self-complementary oligonucleotides and thrombin binding aptamers (TBA) carrying the acridine and quindoline molecules are studied by NMR.

Countries

Italy, Spain

Related Organizations

University of Milan
Italy
Spanish National Research Council
Spain
Institute for Research in Biomedicine
Spain

Keywords

Models, Molecular, Indoles, Magnetic Resonance Spectroscopy, DNA duplex, Oligonucleotides, DNA-binding drugs, Quindoline, Thrombin binding aptamer, Nucleic Acid Denaturation, Quadruplex, Alkaloids, Threoninol, Acridine, Butylene Glycols, Circular Dichroism, DNA, Aptamers, Nucleotide, Amino Alcohols, NMR, oligonucleotide synthesis ; DNA duplex ; DNA-binding drugs ; DNA ; intercalating agents ; acridine ; quindoline ; threoninol ; quadruplex ; thrombin binding aptamer ; NMR, Intercalating agents, Quinolines, Acridines, Nucleic Acid Conformation, Oligonucleotide synthesis

11 Research products, page of 2

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	16
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%