LC-MS-SPE-NMR for the Isolation and Characterization of neo-Clerodane Diterpenoids from Teucrium luteum subsp. flavovirens

descriptionPublicationkeyboard_double_arrow_right Article 10 May 2010 Netherlands English Publisher:American Chemical Society (ACS)Journal:Journal of Natural Products, volume 73, pages 962-965 (issn: 0163-3864, eissn: 1520-6025,

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Authors: Castro, A.; Moco, S.I.A.; Coll, J.; Vervoort, J.J.M.;

doi: 10.1021/np9005025

handle: 10261/42211

LC-MS-SPE-NMR for the Isolation and Characterization of neo-Clerodane Diterpenoids from Teucrium luteum subsp. flavovirens

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Abstract

neo-Clerodane diterpenes of plant origin are molecules difficult to monitor due to their nonspecific UV/vis absorption. The present work describes for the first time the application of the LC-MS-SPE-NMR technique for the isolation and characterization of three new neo-clerodane diterpenes, 3β-hydroxyteucroxylepin and teuluteumin A and teuluteumin B, from Teucrium luteum subsp. flavovirens, harvested from two different locations.

This research was supported by the European Community Activity Large-Scale Facility Wageningen NMR Center (FP6-2004-026164 (2006-2009)). Financial support from MCYT (project AGL2004/05252) and an associated grant (Beca Predoctoral de Formacio´n de Personal Investigador BES-2005-9474, to A.C.) as well as META-PHOR (FOOD-CT- 2006-036220, to S.M.) is gratefully acknowledged.

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Peer reviewed

Country

Netherlands

Related Organizations

Wageningen University & Research
Netherlands
Institute of Advanced Chemistry of Catalonia
Spain
Spanish National Research Council
Spain

Keywords

cytotoxic clerodane diterpenoids, rain-forest, madagascar, stereochemistry, croton-cajucara, ajuga, structural elucidation, antifeedant activity, biological-activity, scutellaria

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