Intracellular machinery for the transport of AMPA receptors

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 2008 United States English Publisher:WileyJournal:British Journal of Pharmacology, volume 153 (issn: 0007-1188, eissn: 1476-5381,

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Authors: Esteban, J. A.;

doi: 10.1038/sj.bjp.0707525

pmid: 18026130

pmc: PMC2268045

handle: 10261/40051 , 2027.42/73173

Intracellular machinery for the transport of AMPA receptors

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Abstract

AMPA‐type glutamate receptors are one of the most dynamic components of excitatory synapses. Their regulated addition and removal from synapses leads to long‐lasting forms of synaptic plasticity, known as long‐term potentiation (LTP) and long‐term depression (LTD). In addition, AMPA receptors reach their synaptic targets after a complicated journey involving multiple transport steps through different membrane compartments. This review summarizes our current knowledge of the trafficking pathways of AMPARs and their relation to synaptic function and plasticity.British Journal of Pharmacology(2008)153, S35–S43; doi:10.1038/sj.bjp.0707525; published online 19 November 2007

Country

United States

Related Organizations

University of Michigan
United States
University of Michigan–Flint
United States
University of Michigan–Ann Arbor
United States

Keywords

Neuronal Plasticity, Long-Term Potentiation, Biological Transport, Active, Membrane trafficking, Endosomes, Endoplasmic Reticulum, Hippocampus, Synaptic plasticity, Exocytosis, Spine, Substrate Specificity, PDZ Protein, Membrane Trafficking, Pharmacy and Pharmacology, Health Sciences, Synapses, Animals, Humans, PDZ protein, Receptors, AMPA, Cytoskeleton, Synaptic Plasticity

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