Interaction of the bacteriophage φ29 connector protein with the viral DNA

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 1986 English Publisher:Elsevier BVJournal:Virology, volume 155, pages 289-292 (issn: 0042-6822,

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Authors: Herranz, Lucía; Salas, Margarita; Carrascosa, José L.;

doi: 10.1016/0042-6822(86)90191-1

pmid: 3095983

handle: 10261/39206

Interaction of the bacteriophage φ29 connector protein with the viral DNA

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Abstract

The protein that forms the connector of phage phi 29, p10, binds to DNA. Apparently, p10 binding is not sequence specific. Nevertheless, the presence of the terminal protein (p3) covalently attached to the ends of phi 29 DNA produces a significant increase of p10 molecules bound to the DNA ends, thus suggesting a terminal protein-mediated recognition of DNA ends by the phage connector. As the p3-DNA complex is the substrate for phage phi 29 DNA packaging, these results may reflect a direct implication of the phage connector in the packaging process.

Related Organizations

Spanish National Research Council
Spain
Autonomous University of Madrid
Spain

Keywords

DNA-Binding Proteins, Microscopy, Electron, Viral Proteins, DNA, Viral, Morphogenesis, Bacteriophages, Virus Replication, Bacillus subtilis

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