Synaptology of the proximal segment of pyramidal cell basal dendrites
Copyright policy )Synaptology of the proximal segment of pyramidal cell basal dendrites
AbstractPyramidal neurons are covered with dendritic spines, the main postsynaptic targets of excitatory (asymmetrical) synapses. However, the proximal portion of both the apical and basal dendrites is devoid of spines, suggesting a lack of excitatory inputs to this region. In the present study we used electron microscopy to analyse the proximal region of the basal dendrites of supra‐ and infragranular pyramidal cells to determine if this is the case. The proximal region of 80 basal dendrites sampled from the rat hindlimb representation in the primary somatosensory cortex was studied by electron microscopy. A total of 317 synapses were found within this region of the dendrites, all of which were of the symmetrical type. These results suggest that glutamate receptors, although present in the cytoplasm, are not involved in synaptic junctions in the proximal portion of the dendrites. These data further support the idea that inhibitory terminals exclusively innervate the proximal region of basal dendrites.
- University of Queensland Australia
- Ben-Gurion University of the Negev Israel
- Spanish National Research Council Spain
- Cajal Institute Spain
- University of Queensland Australia
Male, Cortical circuits, 571, Cortical Circuits, 270502 Neurobiology, Rat Cerebral Cortex, http://metadata.un.org/sdg/3, Protein-synthesis, Rat Neocortex, C1, Layer-iv, Animals, Apical Dendrites, Rats, Wistar, Rat neocortex, Axon Initial Segment, Ensure healthy lives and promote well-being for all at all ages, 780105 Biological sciences, Pyramidal Cells, Neurosciences, Synaptic Input, Dendrites, Somatosensory Cortex, Mouse Smi Cortex, Rats, Microscopy, Electron, Corticothalamic Cells, Inhibitory Synapses, Synapses, Cat Visual-cortex, Female, Inhibitory synapses
Male, Cortical circuits, 571, Cortical Circuits, 270502 Neurobiology, Rat Cerebral Cortex, http://metadata.un.org/sdg/3, Protein-synthesis, Rat Neocortex, C1, Layer-iv, Animals, Apical Dendrites, Rats, Wistar, Rat neocortex, Axon Initial Segment, Ensure healthy lives and promote well-being for all at all ages, 780105 Biological sciences, Pyramidal Cells, Neurosciences, Synaptic Input, Dendrites, Somatosensory Cortex, Mouse Smi Cortex, Rats, Microscopy, Electron, Corticothalamic Cells, Inhibitory Synapses, Synapses, Cat Visual-cortex, Female, Inhibitory synapses
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