Se detallan los seis artículos que forman el cuerpo principal de esta Tesis Doctoral: 1. Adjuvants influence the immune cell populations present at the injection site granuloma induced by whole-cell inactivated paratuberculosis vaccines in sheep. 2. Evaluation of alternative immunization strategies against paratuberculosis in goats. (En revisión) 3. Analysis of the mucosal response in goats to paratuberculosis infection and the impact of vaccination via different routes. (En preparación) 4. Local assessment of WC1+ γδ T lymphocyte subset in the different types of lesions associated with bovine paratuberculosis. 5. Evaluation of the innate immune response of caprine neutrophils against Mycobacterium avium subspecies paratuberculosis in vitro. 6. No evidence of neutrophil response modulation in goats after Immunization against paratuberculosis with a heat-Inactivated vaccine

Criado, M.; Benavides, J.; Vallejo, R.; Arteche, N.; Gutiérrez-Expósito, D.; Ferreras, M.C.; Pérez, V.; Espinosa, J. 2020. Local assessment of WC1+ γδ T lymphocyte subset in the different types of lesions associated with bovine paratuberculosis. Comparative Immunology Microbiology and Infectious Diseases: 69: 101422. http://dx.doi.org/10.1016/j.cimid.2020.101422

Criado, M.; Reyes, L.E.; García Marín, J.F.; Gutiérrez-Expósito, D.; Zapico, D.; Espinosa, J.; Pérez, V., 2024. Adjuvants influence the immune cell populations present at the injection site granuloma induced by whole-cell inactivated paratuberculosis vaccines in sheep. Front Vet. Sci. 11: 1284902. http://dx.doi.org/10.3389/fvets.2024.1284902

Criado, M.; Pérez, V.; Arteche-Villasol, N.; Elquezabal, N.; Molina, E.; Benavides, J.; Gutiérrez-Expósito, D. 2023. Evaluation of the innate immune response of caprine neutrophils against Mycobacterium avium subspecies paratuberculosis in vitro. Veterinary Research. 54: 61. http://dx.doi.org/10.1186/s13567-023-01193-7

Criado, M.; Silva, M.; Mendívil, P.; Molina, E.; Pérez, V.; Benavides, J.; Elguezabal, N.; Gutiérrez-Expósito, D. 2024. No evidence of neutrophil response modulation in goats after Immunization against paratuberculosis with a heat-Inactivated vaccine. Animals: 14 (11), 1694. https://doi.org/10.3390/ani14111694

Peer reviewed