A Growth Modulation Index-Based GEISTRA Score as a New Prognostic Tool for Trabectedin Efficacy in Patients with Advanced Soft Tissue Sarcomas: A Spanish Group for Sarcoma Research (GEIS) Retrospective Study
Copyright policy )A Growth Modulation Index-Based GEISTRA Score as a New Prognostic Tool for Trabectedin Efficacy in Patients with Advanced Soft Tissue Sarcomas: A Spanish Group for Sarcoma Research (GEIS) Retrospective Study
The aim of this study was to identify an easily reliable prognostic score that selects the subset of advanced soft tissue sarcoma (ASTS) patients with a higher benefit with trabectedin in terms of time to progression and overall survival. A retrospective series of 357 patients with ASTS treated with trabectedin as second- or further-line in 19 centers across Spain was analyzed. First, it was confirmed that patients with high growth modulation index (GMI > 1.33) were associated with the better clinical outcome. Univariate and multivariate analyses were performed to identify factors associated with a GMI > 1.33. Thus, GEISTRA score was based on metastasis free-interval (MFI ≤ 9.7 months), Karnofsky < 80%, Non L-sarcomas and better response in the previous systemic line. The median GMI was 0.82 (0–69), with 198 patients (55%) with a GMI < 1, 41 (11.5%) with a GMI 1–1.33 and 118 (33.1%) with a GMI > 1.33. The lowest GEISTRA score showed a median of time-to-progression (TTP) and overall survival (OS) of 5.7 and 19.5 months, respectively, whereas it was 1.8 and 3.1 months for TTP and OS, respectively, for the GEISTRA 4 score. This prognostic tool can contribute to better selecting candidates for trabectedin treatment in ASTS.
Leiomyosarcoma, Advanced soft tissue sarcomas, sarcoma, Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia, GEISTRA, Trabectedina, Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Sulfur Compounds::Thiazoles::Thiamine::Thiamine Triphosphate, España, Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Connective and Soft Tissue::Sarcoma::Liposarcoma, Thiamine Triphosphate, Growth modulation index, Article, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans, DISEASES::Neoplasms::Neoplasms by Site::Soft Tissue Neoplasms, Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Connective and Soft Tissue::Sarcoma, Humans, PUBLIC HEALTH::Epidemiology and Biostatistics::Epidemiology::Uses of Epidemiology::Effectiveness, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis, Retrospective Studies, Other subheadings::Other subheadings::Other subheadings::/drug therapy, Tumors de parts toves, SALUD PÚBLICA::epidemiología y bioestadística::epidemiología::usos de la epidemiología::efectividad, Pronóstico, Sarcoma, Liposarcoma, Medical Subject Headings::Geographical Locations::Geographic Locations::Europe::Spain, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Analysis of Variance::Multivariate Analysis, Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Connective and Soft Tissue::Sarcoma::Leiomyosarcoma, Prognosis, prognostic score, GEISTRA, L-sarcoma, growth modulation index, prognostic score, sarcoma, trabectedin, Spain, Prognostic score, trabectedin, Multivariate Analysis, Medicaments - Eficàcia, ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de los tejidos blandos, L-sarcoma, Leiomiosarcoma, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies::Retrospective Studies, growth modulation index, Trabectedin
Leiomyosarcoma, Advanced soft tissue sarcomas, sarcoma, Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia, GEISTRA, Trabectedina, Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Sulfur Compounds::Thiazoles::Thiamine::Thiamine Triphosphate, España, Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Connective and Soft Tissue::Sarcoma::Liposarcoma, Thiamine Triphosphate, Growth modulation index, Article, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans, DISEASES::Neoplasms::Neoplasms by Site::Soft Tissue Neoplasms, Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Connective and Soft Tissue::Sarcoma, Humans, PUBLIC HEALTH::Epidemiology and Biostatistics::Epidemiology::Uses of Epidemiology::Effectiveness, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis, Retrospective Studies, Other subheadings::Other subheadings::Other subheadings::/drug therapy, Tumors de parts toves, SALUD PÚBLICA::epidemiología y bioestadística::epidemiología::usos de la epidemiología::efectividad, Pronóstico, Sarcoma, Liposarcoma, Medical Subject Headings::Geographical Locations::Geographic Locations::Europe::Spain, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Analysis of Variance::Multivariate Analysis, Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Connective and Soft Tissue::Sarcoma::Leiomyosarcoma, Prognosis, prognostic score, GEISTRA, L-sarcoma, growth modulation index, prognostic score, sarcoma, trabectedin, Spain, Prognostic score, trabectedin, Multivariate Analysis, Medicaments - Eficàcia, ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de los tejidos blandos, L-sarcoma, Leiomiosarcoma, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies::Retrospective Studies, growth modulation index, Trabectedin
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