Integrator complex subunit 6 (INTS-6) mediates DNA damage response in Caenorhabditis elegans.
Copyright policy )Integrator complex subunit 6 (INTS-6) mediates DNA damage response in Caenorhabditis elegans.
The Caenorhabditis elegans Integrator complex is a set of at least 13 evolutionarily conserved proteins that binds the C-terminal domain of RNA polymerase II to regulate snRNA 3'-end processing and gene expression. Here we show that the Integrator subunit 6 intervenes in the DNA damage response in C. elegans . We find that upon X-ray radiation, INTS-6 is necessary for RAD-51 foci formation. In addition, CDK-1 Tyr-15 phosphorylation depends on the presence of INTS-6 . This work adds a new piece to elucidate the Integrator complex mechanism of action in DNA repair.
This research was funded by the Ministerio de Ciencia e Innovación (grant PID2021- 127388NB-I00), Rioja Salud Foundation and the Spanish Association Against Cancer (AECC).
Peer reviewed
- Instituto de Biología Funcional y Genómica Spain
- University of Salamanca Spain
- University of Seville Spain
- Oslo University Hospital Norway
- University of Oslo Norway
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